Lipid-Based Nanosystems for the Topical Application of Ferulic Acid: A Comparative Study

In this study, we examined and compared two different lipid-based nanosystems (LBNs), namely Transferosomes (TFs) Monoolein Aqueous Dispersions (MADs), as delivery systems for the topical application of Ferulic Acid (FA), an antioxidant molecule derived from natural sources. Our results, demonstrated through Franz-cell experiments, indicate that LBNs produced with poloxamer 188 in their composition create a multilamellar system. This system effectively controls release drug. Nonetheless, found type non-ionic surfactant can impact drug rate. Regarding FA diffusion MAD, showed lower rate TF. terms vivo application, patch tests revealed all LBN formulations tested were safe when applied under occlusive conditions 48 h. Additionally, human skin biopsies used to determine whether FA-containing could influence tissue morphology or provide protection against O3 exposure. Analyses suggest treatment TFs composed MAD might protect structural damage (as observed hematoxylin/eosin staining) development oxidative environment indicated by 4-hyroxinonenal (4HNE) expression levels) induced contrast, without active ingredient did not offer detrimental effects exposure.Inizio modulo.